Custom Curation Services

Services Overview:

The world today is full of unstructured and scattered Information which is being generated rapidly by scientific communities & research organizations, but the wealth of information is wasted unless it is structured, packaged and presented in a manner it can be utilized to meet the rapidly changing consumer requirements.

Perhaps the most challenging aspect of informatics literature faced by many researchers, publishers, academic scholars and regulators/governments today is refining the every important variable hidden in the vast wealth of information impacting ultimate success of a research or business objective.

Molecular connections informatics services are designed for scientists and engineers to finding solutions in drug discovery and patent mining.

Customized Curation Services:

Molecular Connections, Custom Curation Services have evolved over a decade, working with top-notch Pharmaceutical & research institutions. It leverages our Proprietary workflow systems for target curation, The system is an extremely modular end-to-end platform for literature mining with Automatic or Manual or Hybrid approach and includes comprehensive quality control steps thus, translating large volumes of experimental data into research-ready content in a structured form.

Such curated information can optimize the flow of information across an enterprise and facilitate faster access to the mission-critical scientific information
Our customized & cost effective solutions help in the areas such as data mining, data abstraction, indexing and annotation of chemical, biological, pharmacological and toxicity information from journals, patents or any other sources specified by clients. Information is curated in customized formats to meet specific end user requirement.

Utilizing extensive ontologies and semantic data mining, combined with our scientific expert quality assurance methodologies, we build target specific or disease specific knowledgebases.

Our flexible delivery formats range from XML/XL/RDF files, MS Access format with a custom Windows-based or Web interface or any format that can be best suitable to the end-user requirement.
We assist our clients to increase their R&D productivity across Drug Discovery value chain including medicinal chemistry, biology, Target discovery, Target validation, Lead optimization etc

Literature Informatics spans across Discovery value chain

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Target discovery: identification, mode of action, drugability, pharmacological properties of lead compounds, identifying diseases mechanism etc.

Target validation: analysis of gene knockout/in, gene and gene products pathways, chemical structures to biological effects, chemical knockout studies etc.

Lead optimization: SAR, predictive PK/PD /ADME studies etc.

Some case studies:

• Literature curation: Data mining / curation / annotation, Patent curation (English & Non-english), Data integration
  Examples: Prioritized Database Development for genes of interest
• Relational Knowledgebases: Target specific, Protein-Protein interactions, drug molecules, SAR, ADME-T, Biomarkers
  Examples: Database development of adverse effects
• Pathway Analysis: Biochemical static and network regulatory maps, gene regulatory networks, disease pathways
  Examples: Structural Prediction & Active Site Modelling
• Drug Profiling: Chemical names, structures, metabolic breakdown, PK/PD, drug-drug interactions, drug-protein interactions, adverse events
  Examples: Medicinal Chemistry database annotation
• Pipeline compounds Competitive Intelligence: Identify compounds in various Phases of development for given therapeutic areas – both small molecules and biologics.
• Ontology Development: Developing taxonomies ( standard terminology) and ontology for biomedical speciality.
• InSilico Analysis: Modelling, enzyme interactions, activity predictions & analysis backed by evidence based literature, perturbation analysis.